The application prospect of chlortetracycline hydrochloride

Chlortetracycline has always been well known by practitioners for its good bacteriostatic effect, low residue in vivo, improving feed utilization rate and promoting

Chlortetracycline  has always been well known by practitioners for its good bacteriostatic effect, low residue in vivo, improving feed utilization rate and promoting animal growth.

The chlortetracycline we mentioned in the past usually refers to the premix of chlortetracycline in the form of insoluble calcium salt, which is hardly absorbed in the intestinal tract, and long-term low-dose addition to the feed inhibits the reproduction of bacteria. promote growth. In July 2019, the Ministry of Agriculture's Announcement No. 194 was officially promulgated, announcing that chlortetracycline premix as a medicated feed additive will end its 70-year history of feed addition on July 1, 2020. How to continue to exert the bacteriostatic and growth-promoting effects of chlortetracycline in the breeding field is a common concern of the industry. methods and applications.

As the most widely used broad-spectrum antibiotic in veterinary clinic, chlortetracycline hydrochloride can inhibit the occurrence of chronic and recessive diseases, promote the growth of livestock and poultry, and improve the utilization rate of feed, thereby improving economic benefits. The use of medium and high doses can be used as preventive or therapeutic drugs for the prevention and treatment of chronic respiratory diseases, colibacillosis, Mycoplasma synovialis, bacterial enteritis, etc., and the withdrawal period is only 8 days. In animal husbandry, chlortetracycline also has a preparation form "chlortetracycline hydrochloride soluble powder". The chlortetracycline hydrochloride soluble powder of Arshine Animal Pharmaceutical is prepared by mixing chlortetracycline hydrochloride with a suitable carrier. , chlortetracycline exists in an ionic state. After livestock and poultry drink, a small part is complexed with metal ions, acting on the intestine, inhibiting bacteria and promoting growth; most of it is absorbed into the blood circulation, acting on the whole body, and exerting a broad-spectrum antibacterial effect.

In the breeding of white-feathered broilers, chlortetracycline is currently used relatively little. With the increasingly strict restrictions on drug residues in white feather broilers, some breeding enterprises have begun to pay attention to the use of chlortetracycline hydrochloride. After 2 years of clinical application verification, the Arshine has concluded the intermittent three-stage use plan (for detailed consultation or call the Arshine official website customer service), the slaughter weight can be increased by 50g, the mortality rate can be reduced by 6%, and effective prevention Chronic respiratory disease caused by vaccine immunization, Clostridial enteritis, promotion of broiler growth.

For the prevention and treatment of Mycoplasma synovialis, which has a high incidence of yellow feather chickens and 817 hybrid chickens, the experience summarized by the Arshine is to use sensitive macrolide drugs such as tilmicosin , tylosin , and tylosin . Wanmectin and other compatible chlortetracycline hydrochloride soluble powder, every 500 grams of 500 kg of water, used for 5-7 days, achieved good results, recognized by the majority of farming friends, is one of the few practical solutions.

In terms of disease prevention and control in commercial meat ducks, chlortetracycline is one of the sensitive drugs ignored by the majority of veterinarians. The latest drug susceptibility test results show that chlortetracycline hydrochloride soluble powder is highly sensitive to Riemerella anatipestifer. Arshine recommends the use of chlortetracycline hydrochloride soluble powder combined with florfenicol solution to prevent and control infectious serositis in ducklings. Every 500 grams of 500 kg of water is used for 3-5 days, which can significantly reduce infectious serositis. incidence rate.

However, due to the uneven quality of commercially available chlortetracycline hydrochloride soluble powder, the therapeutic effect is still controversial. The main reason is that the form of chlortetracycline in the  chlortetracycline hydrochloride  soluble powder determines the bioavailability of chlortetracycline, and also determines the clinical indications. The simple and intuitive method to evaluate the bioavailability of chlortetracycline hydrochloride soluble powder is to observe its water solubility. It is combined or epimerized and exists in a stable ionic state, which indirectly indicates that the product has good bioavailability.

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